SCAP/SREBP2-Mediated Cholesterol Biosynthetic Pathway Suppresses Particulate Matter-Induced Macrophage Activation and Airway Inflammation
The SCAP/SREBP2-mediated cholesterol synthesis pathway inhibits macrophage activation and airway inflammation induced by PM through the production of cholesterol.
Authors
- Chen Zhu (ORCID: https://orcid.org/0000-0002-1002-8387)
- Jiaqi Huang (ORCID: https://orcid.org/0000-0002-7808-9477)
- Wei-Song Chen
- Yuanqiang Zhang (ORCID: https://orcid.org/0000-0002-4592-4966)
- Wen Li (ORCID: https://orcid.org/0000-0002-8981-8380)
- Zhihua Chen (ORCID: https://orcid.org/0000-0002-4390-7636)
- Miao Li
- Yan-Ping Wu
- Shenwei Gao
- Jieyu Li (ORCID: https://orcid.org/0000-0001-8868-6905)
- Jia-Fei Lou
- Yin-Fang Wu
- Kua Zheng
Institutions
- Wenzhou Medical University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Jinhua Central Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s527083
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00