Nuclear eNOS Interacts With and <i>S</i> -Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function
Our findings uncovered a novel mechanism linking nuclear eNOS-derived NO with the activity of ADAR1 to maintain vascular homeostasis. Reduced NO bioavailability results in previously unrecognized activation of a type I IFN response in the endothelium, which contributes to atherogenesis.
Authors
- Ilka Wittig (ORCID: https://orcid.org/0000-0002-9751-8054)
- Nadja Sachs (ORCID: https://orcid.org/0000-0001-8031-017X)
- Christian Münch (ORCID: https://orcid.org/0000-0003-3832-090X)
- Fredy Delgado Lagos (ORCID: https://orcid.org/0000-0003-2096-9858)
- Xiaozhu Zhou
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Mauro Siragusa (ORCID: https://orcid.org/0000-0002-5862-5156)
- Carsten Kuenne (ORCID: https://orcid.org/0000-0001-8013-5906)
- Stefan Günther (ORCID: https://orcid.org/0000-0002-5594-4549)
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Stefan Offermanns (ORCID: https://orcid.org/0000-0001-8676-6805)
- Ingrid Fleming (ORCID: https://orcid.org/0000-0003-1881-3635)
- Doha Boutguetait
- Beyza Güven (ORCID: https://orcid.org/0009-0001-6027-1334)
Institutions
- Goethe University Frankfurt (DE)
- Karolinska University Hospital (SE)
- TUM Klinikum (DE)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- German Centre for Cardiovascular Research (DE)
- Center for Vascular Biology Research (US)
- Institute of Molecular Medicine (IN)
- Cardio-Pulmonary Institute (DE)
- Clinical Research Center Kiel (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Circulation
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1161/circulationaha.125.074889
- Citations
- 3
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42