A Novel High‐Safety Filler with Potential Periosteal Enhancement: In Vivo Evaluation of Cross‐Linked Sodium Hyaluronate Gel with PVA Microspheres in Rat Models
The novel PVA/HA filler demonstrated strong structural support in both the periosteum and subcutaneous tissue. The filler provides enhanced periosteal angiogenesis, promotes periosteal thickening, and stimulates collagen fiber formation, while exhibiting minimal inflammation, high safety, and no risk of hyperplasia.
Authors
- Shiwei Wang (ORCID: https://orcid.org/0000-0002-4562-3127)
- Huanyun Niu
- Dongmei Tan (ORCID: https://orcid.org/0000-0002-1520-5071)
- Yuchen Dai (ORCID: https://orcid.org/0000-0002-8960-4040)
- Zhen Li (ORCID: https://orcid.org/0000-0001-8114-2518)
- Xiaowen Liu (ORCID: https://orcid.org/0000-0002-2013-7851)
Institutions
- Chongqing Academy of Animal Science (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1111/jocd.70522
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University