Age- and Sex-Related Normative Anterior Segment Parameters Using Swept-Source OCT: Insights from Pediatric to Elderly Populations

<b>Objectives</b>: To establish normative data for anterior segment parameters in healthy pediatric and adult populations using swept-source optical coherence tomography (SS-OCT), and to evaluate the influence of age and sex on these parameters. <b>Methods</b>: This retrospective study included the right eyes of 390 healthy participants. Subjects were divided into three age groups: Group 1 (6-17 years, <i>n</i> = 97), Group 2 (18-45 years, <i>n</i> = 144), and Group 3 (46-77 years, <i>n</i> = 149). All patients were categorized according to their biological sex as female and male. Exclusion criteria were corneal pathology, prior intraocular/refractive surgery, recent contact lens use, severe dry eye, ectatic disorders, low-quality imaging, and refractive error of ±2.0 D or greater. Measurements of anterior and posterior keratometry, total corneal power (TCP), central corneal thickness (CCT), thinnest corneal thickness (TCT), pupil diameter (PD), lens thickness (LT), and white-to-white distance (WTW) were obtained using the Anterion^® SS-OCT system. Data were analyzed using SPSS software. <b>Results</b>: Group 1 demonstrated the highest PD and CCT values, whereas LT was lowest. In adults, LT increased with age and was significantly higher in males older than 45 years. Keratometric analysis revealed greater anterior and total steep astigmatism in the pediatric group, independent of sex. Adult females had significantly higher anterior and posterior keratometry values compared with males. In the pediatric cohort, females exhibited greater CCT, while WTW varied with age. PD decreased with age, whereas LT increased. <b>Conclusions</b>: Anterior segment parameters measured with SS-OCT show significant variations across different age groups and between sexes. Normative data, particularly for pediatric and adult populations, may serve as valuable reference values in keratorefractive surgical planning and corneal pathology assessment. Future studies with larger cohorts, especially in pediatric populations, are warranted.