New analgesics in oncology. Tafalgin employed as an alternative to opioid analgesics

The publication presents data on new analgesics that could serve as an alternative to opioids, having a comparable analgesic effect, but with a lower risk of serious adverse events. Tafalgin is a selective agonist of the m1-opioid receptors, due to which it has a decend analgetic effect comparable to opioid analgesics with a more favorable safety profile, which has been demonstrated both in clinical studies and in real clinical practice. Tafalgin has been introduced into clinical practice relatively recently, so there are few publications revealing the specifics of its use in various clinical situations. The presented clinical observation describes the possibility of taking Tafalgin not only as a drug for the treatment of acute or breakthrough pain, but also as a basic analgesic for intensity pain syndromes, especially in situations where taking opioid analgesics is undesirable or impossible for any reason.

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Publication Details

Journal
P A Herzen Journal of Oncology
Published
2025-10-29
DOI
https://doi.org/10.17116/onkolog20251405173
Primary Topic
Pain Management and Opioid Use
Type
article
Field-Weighted Citation Impact
0.00
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article

New analgesics in oncology. Tafalgin employed as an alternative to opioid analgesics

Р. Р. Сарманаева, Yu.V. Brazhnikova, Guzal R. Abuzarova
P A Herzen Journal of Oncology
Pain Management and Opioid Use
article

New analgesics in oncology. Tafalgin employed as an alternative to opioid analgesics

Р. Р. Сарманаева, Yu.V. Brazhnikova, Guzal R. Abuzarova
article en

Abstract

The publication presents data on new analgesics that could serve as an alternative to opioids, having a comparable analgesic effect, but with a lower risk of serious adverse events. Tafalgin is a selective agonist of the m1-opioid receptors, due to which it has a decend analgetic effect comparable to opioid analgesics with a more favorable safety profile, which has been demonstrated both in clinical studies and in real clinical practice. Tafalgin has been introduced into clinical practice relatively recently, so there are few publications revealing the specifics of its use in various clinical situations. The presented clinical observation describes the possibility of taking Tafalgin not only as a drug for the treatment of acute or breakthrough pain, but also as a basic analgesic for intensity pain syndromes, especially in situations where taking opioid analgesics is undesirable or impossible for any reason.

P A Herzen Journal of OncologyVol. 14(5)
Russian Medical Academy of Continuous Professional Education (RU), P.A. Hertzen Moscow Oncology Research Institute (RU)
Openalex Percentile: Top 51%
Pain Management and Opioid Use
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