Unveiling metabolic pathway dysregulation in the malignant transformation of polyps to colorectal cancer: a single-cell analysis of epithelial cell trajectories

This study elucidates the malignant evolution of epithelial cells, along with changes in metabolic pathway activity and key regulators, jointly promote CRC development. This research provides new insights into early CRC detection from the perspective of metabolic reprogramming, while nominating candidate targets worthy of further investigation for precise treatment strategies.