The Safety and Efficacy of Platelet-Rich Plasma in Enhancing Outcomes Following Circumcision in Children

<b>Background</b>: The primary objectives of platelet-rich plasma (PRP) therapy are to enhance the wound-healing process, reduce pain, and minimize the loss of productivity due to recovery time. Localized application of PRP, which is enriched with growth factors such as PDGF, TGF-β1, IGF-1, VEGF, and FGF-2, as well as interleukins (IL-1, IL-4, IL-6, IL-10, and IL-13), has been documented to accelerate the healing process by approximately 30-40%. This study aimed to assess the safety and efficacy of platelet-rich plasma (PRP) in enhancing outcomes following circumcision in male children. <b>Methods</b>: The patients were divided into two groups: one undergoing standard circumcision and the other receiving PRP application during circumcision. Pain scores, edema level, bleeding, local infection, and safety of PRP were evaluated. <b>Results</b>: This study evaluated 80 male children undergoing circumcision, divided into two groups: Group CS (n = 44) underwent classical circumcision, and Group PRP (n = 36) received PRP application. Median ages were comparable (<i>p</i> = 0.101). Penile edema occurred less frequently in the PRP group (5.6%) compared to the CS group (18.2%) (<i>p</i> = 0.089), with no severe edema observed in the PRP group. Postoperative bleeding was present in 6.8% of the CS group but absent in the PRP group (<i>p</i> = 0.110). Other complications, such as nausea (CS: 6.8%, PRP: 5.6%, <i>p</i> = 0.816), vomiting (CS: 4.5%, PRP: 2.8%, <i>p</i> = 0.679), local infection (CS: 2.3%, PRP: 0%, <i>p</i> = 0.363), wound dehiscence (CS: 2.3%, PRP: 0%, <i>p</i> = 0.363), and skin tunnel formation (CS: 6.8%, PRP: 2.8%, <i>p</i> = 0.409), showed no significant differences. No cases of necrosis, chordee, rotational anomaly, or secondary phimosis were observed. Safety analysis of PRP revealed minor complications during blood draw: hypotension in one patient (2.8%) and local ecchymosis in two patients (5.6%), resolving without intervention. During PRP application, one allergic reaction (2.8%) occurred, presenting as a transient rash that resolved spontaneously. Group PRP consistently reported lower pain scores than Group CS at all time points. <b>Conclusions</b>: PRP application during circumcision is safe. The findings provide preliminary but important evidence regarding the potential benefits of PRP in pediatric circumcision.