Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents
This study offers evidence implicating PFHpA, a short-chain unregulated PFAS congener, in MASLD development in adolescents, and highlights the critical role of protein dysregulation in disease pathogenesis. The molecular mechanisms identified here can inform the development of targeted prevention and treatment strategies.
Authors
- David V. Conti (ORCID: https://orcid.org/0000-0002-2941-7833)
- Matthew P. Salomon (ORCID: https://orcid.org/0000-0002-3935-5306)
- Justin R. Ryder (ORCID: https://orcid.org/0000-0002-7506-9497)
- Damaskini Valvi (ORCID: https://orcid.org/0000-0003-4633-229X)
- Sandrah Proctor Eckel (ORCID: https://orcid.org/0000-0001-6050-7880)
- David E. Kleiner (ORCID: https://orcid.org/0000-0003-3442-4453)
- Hongxu Wang (ORCID: https://orcid.org/0000-0001-5248-4578)
- Scott M. Bartell (ORCID: https://orcid.org/0000-0001-7797-2906)
- Lucy Golden‐Mason (ORCID: https://orcid.org/0000-0002-2087-4405)
- Brittney O. Baumert (ORCID: https://orcid.org/0000-0003-1220-8557)
- Stavra A. Xanthakos (ORCID: https://orcid.org/0000-0001-9179-005X)
- Lida Chatzi (ORCID: https://orcid.org/0000-0002-3319-2438)
- Sarah Rock (ORCID: https://orcid.org/0000-0002-9851-2594)
- Thomas H. Inge (ORCID: https://orcid.org/0000-0001-7782-1112)
- Max T. Aung (ORCID: https://orcid.org/0000-0001-5541-5447)
- Rob McConnell (ORCID: https://orcid.org/0000-0001-5243-6410)
- Stephanie Sisley (ORCID: https://orcid.org/0000-0003-2900-7014)
- Ana C. Maretti‐Mira (ORCID: https://orcid.org/0000-0002-6252-2811)
- Douglas G. Walker (ORCID: https://orcid.org/0000-0001-5126-7926)
- Jesse A. Goodrich (ORCID: https://orcid.org/0000-0001-6615-0472)
- Fabian C. Fischer (ORCID: https://orcid.org/0000-0002-9511-0506)
- Todd Jenkins (ORCID: https://orcid.org/0000-0003-2669-3813)
- Rohit Kohli (ORCID: https://orcid.org/0000-0002-0198-7703)
- Michele A. La Merrill (ORCID: https://orcid.org/0000-0002-5720-5862)
- Nikos Stratakis (ORCID: https://orcid.org/0000-0003-4613-0989)
- Qiran Jia (ORCID: https://orcid.org/0000-0002-0790-5967)
- Jiawen Chen (ORCID: https://orcid.org/0000-0002-6022-9646)
- Zhenjiang Li (ORCID: https://orcid.org/0000-0002-4806-6231)
- Yinqi Zhao
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Cincinnati Children's Hospital Medical Center (US)
- Lurie Children's Hospital (US)
- National Institutes of Health (US)
- Children's Hospital of Los Angeles (US)
- Emory University (US)
- University of Rhode Island (US)
- Baylor College of Medicine (US)
- University of California, Irvine (US)
- National Cancer Institute (US)
- Barcelona Institute for Global Health (ES)
- Center for Cancer Research (US)
- University of Cincinnati (US)
- University of California, Davis (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1038/s43856-025-01168-z
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- California Environmental Protection Agency
- European Commission
- Syddansk Universitet
- National Institutes of Health
- National Institute of Environmental Health Sciences
- National Center for Research Resources
- National Center for Advancing Translational Sciences
- H2020 Marie Skłodowska-Curie Actions