Metastatic Leydig cell tumour in a patient with synchronous prostate cancer

Leydig cell tumours (LCTs) are rare testicular stromal tumours, comprising 1-3% of all testicular neoplasms. While typically benign, malignant transformation occurs in approximately 10% of cases, with metastasis being exceedingly rare. We present a case of a male in his 70s with a history of pT1 Leydig cell tumour who developed metastatic disease to the lungs and para-aortic lymph nodes, discovered during prostate cancer staging. This case highlights the challenges in diagnosing and managing metastatic LCT and underscores the importance of surveillance in patients with rare testicular malignancies.

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Publication Details

Journal
BMJ Case Reports
Published
2025-10-01
DOI
https://doi.org/10.1136/bcr-2025-267782
Primary Topic
Testicular diseases and treatments
Type
article
Field-Weighted Citation Impact
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article

Metastatic Leydig cell tumour in a patient with synchronous prostate cancer

Margaret Mary Mansbridge, Nicholas Gillman, Stuart Ehsman, Jason Kim
BMJ Case Reports
Testicular diseases and treatments
article

Metastatic Leydig cell tumour in a patient with synchronous prostate cancer

Margaret Mary Mansbridge, Nicholas Gillman, Stuart Ehsman, Jason Kim
article en

Abstract

Leydig cell tumours (LCTs) are rare testicular stromal tumours, comprising 1-3% of all testicular neoplasms. While typically benign, malignant transformation occurs in approximately 10% of cases, with metastasis being exceedingly rare. We present a case of a male in his 70s with a history of pT1 Leydig cell tumour who developed metastatic disease to the lungs and para-aortic lymph nodes, discovered during prostate cancer staging. This case highlights the challenges in diagnosing and managing metastatic LCT and underscores the importance of surveillance in patients with rare testicular malignancies.

BMJ Case ReportsVol. 18(10)
Gold Coast Hospital (AU)
Openalex Percentile: Top 51%
Testicular diseases and treatments
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