Cortical morphological alterations and structural covariant network topology changes in children with acute lymphoblastic leukemia
On days 46-52 of chemotherapy, changes in the morphology of the cerebral cortex, and changes in the Deg, Bet, and hub values in the SCN were already present in children with ALL. The bilateral frontal lobe may be the most susceptible brain region for CICI among children with ALL. These results appear to suggest that the topological properties in the brains of these children were reorganized as a compensatory mechanism after chemotherapy.
Authors
- Ke Wei (ORCID: https://orcid.org/0000-0002-7696-0556)
- Ruiyuan Chen (ORCID: https://orcid.org/0000-0002-5891-8717)
- Huirong Mai (ORCID: https://orcid.org/0000-0002-8970-9221)
- Lei Liu (ORCID: https://orcid.org/0000-0002-7226-8423)
- Weiguo Cao (ORCID: https://orcid.org/0000-0002-9613-7102)
- Zhixin Gao
Institutions
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2025-10-29
- DOI
- https://doi.org/10.21037/qims-24-2239
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00