Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study
A substantial proportion of late-onset schizophrenia risk appears modifiable, with mental health and medical history as key contributors. Physical health and natural environment exposure provided protective benefits. Findings supported integrating clinical interventions and structural changes addressing socioeconomic and environmental factors to reduce late-onset schizophrenia burden.
Authors
- Emilio Fernández-Egea (ORCID: https://orcid.org/0000-0003-4128-8955)
- Rudolf N. Cardinal (ORCID: https://orcid.org/0000-0002-8751-5167)
- Alimu Dayimu (ORCID: https://orcid.org/0000-0001-9998-7463)
- Wenbo Song (ORCID: https://orcid.org/0000-0002-1588-8597)
- Qiu‐Yue Dong
- Huizhi Liang (ORCID: https://orcid.org/0000-0003-4408-4528)
- Shanquan Chen (ORCID: https://orcid.org/0000-0002-4724-4892)
- Lei Xu (ORCID: https://orcid.org/0000-0001-8994-5075)
- Xinyu Li (ORCID: https://orcid.org/0009-0007-5575-8221)
- Fan Jiang (ORCID: https://orcid.org/0009-0000-6167-2191)
- Haibo Wang (ORCID: https://orcid.org/0000-0003-0108-2311)
Institutions
- Shandong University (CN)
- University of Cambridge (GB)
- Cancer Research UK Cambridge Center (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Second Hospital of Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- Newcastle University (GB)
- University of Hong Kong (HK)
Publication Details
- Journal
- BMJ Mental Health
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/bmjment-2025-301954
- Citations
- 1
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47