Camellia-like SnSe <sub>2</sub> nanostructures for highly sensitive electrochemical detection of uric acid in urine for handheld point-of-care diagnostics
In this study, we present a camellia-like SnSe<sub>2</sub> nanostructure fabricated through a straightforward solvothermal process and integrated with reduced graphene oxide (rGO) to enable highly sensitive and selective electrochemical uric acid (UA) detection in artificial urine. The SnSe<sub>2</sub>/rGO electrode exhibits excellent electrocatalytic activity towards UA oxidation, enabling a wide linear detection range of 20 nM-200 μM and an ultra-low detection limit of 11.4 nM. To further advance the practical application of this technology in point-of-care testing, we have designed a user-friendly, smartphone-integrated portable analytical device featuring Bluetooth connectivity, capable of providing real-time monitoring of UA levels in urine specimens.
Authors
- Yuezhong Wang (ORCID: https://orcid.org/0000-0001-8037-8588)
- Tao Cai (ORCID: https://orcid.org/0000-0002-9506-1126)
- Li Fu (ORCID: https://orcid.org/0000-0002-5957-7790)
- Houmeng Yang (ORCID: https://orcid.org/0000-0002-4687-5959)
- Hsu‐Sheng Tsai (ORCID: https://orcid.org/0000-0003-0664-3405)
- Cheng‐Te Lin (ORCID: https://orcid.org/0000-0002-7090-9610)
- Lidong Wu (ORCID: https://orcid.org/0000-0002-6397-6516)
- Yufei Fang (ORCID: https://orcid.org/0000-0002-9429-6660)
- Quanwang Liu
- Kaiqiang Sun (ORCID: https://orcid.org/0000-0002-0272-8383)
- Zhiqiang Liang (ORCID: https://orcid.org/0000-0003-4473-8544)
- Chen Ye (ORCID: https://orcid.org/0000-0003-3935-1601)
- Ningbin Zhao
- Peizheng Shi
- Xiancheng Li (ORCID: https://orcid.org/0000-0002-8301-2589)
- Nan Jiang (ORCID: https://orcid.org/0000-0002-5489-7410)
- Zhuang Sun (ORCID: https://orcid.org/0000-0002-8790-5675)
Institutions
- Ningbo University (CN)
- Dalian Medical University (CN)
- Harbin Institute of Technology (CN)
- Chizhou University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Ningbo No. 2 Hospital (CN)
- Ningbo No.6 Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Ningbo Institute of Industrial Technology (CN)
- Chinese Academy of Fishery Sciences (CN)
- Hangzhou Dianzi University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05561j
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 0.00