Metagenomic next-generation sequencing unraveled the characteristic of lung microbiota in patients with checkpoint inhibitor pneumonitis: results from a prospective cohort study
Our study represents the unique characterization of the lung microbiota profiles across distinct CIP subtypes and establishes a diagnostic model for CIP based on the decision tree. These findings emphasize the value of BALF mNGS in improving the diagnosis of CIP.
Authors
- Shangwen He (ORCID: https://orcid.org/0000-0002-7638-5977)
- Xintong Huang (ORCID: https://orcid.org/0009-0004-8904-5105)
- Yaqi Mao (ORCID: https://orcid.org/0009-0009-1381-8841)
- Zhong‐Kai Cui (ORCID: https://orcid.org/0000-0003-3112-9379)
- Xiao-Fang Su (ORCID: https://orcid.org/0000-0001-8709-4182)
- Wei-Ta Huang (ORCID: https://orcid.org/0000-0003-1712-458X)
- Laiyu Liu (ORCID: https://orcid.org/0000-0001-5827-0802)
- Jia-Run Lin (ORCID: https://orcid.org/0009-0002-5082-0552)
- Zhenhua Zhou (ORCID: https://orcid.org/0000-0001-5463-9393)
- Xiaoyue Ge (ORCID: https://orcid.org/0009-0007-2052-0424)
- Hailing Zhang (ORCID: https://orcid.org/0000-0001-7336-3054)
- Junyi Lu (ORCID: https://orcid.org/0009-0002-4220-0513)
- Yongzhong Zhan (ORCID: https://orcid.org/0009-0002-1408-8915)
- Wenxia Xie (ORCID: https://orcid.org/0009-0004-3353-329X)
- Jiaxin Li (ORCID: https://orcid.org/0009-0001-0602-2230)
- Fan Yang
- Dong Yu (ORCID: https://orcid.org/0000-0002-9921-5014)
- Yuan Lu (ORCID: https://orcid.org/0009-0003-5260-771X)
- Meihua Li (ORCID: https://orcid.org/0009-0000-0432-9362)
- Jihong Huang (ORCID: https://orcid.org/0009-0000-3940-7260)
Institutions
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012444
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Guangdong Province
- Southern Medical University
- Nanfang Hospital