Effect of Vitamin D3 Supplements in the Success of Dental Implants: A Comparative Evaluation

Background: Dental implants are a reliable treatment for tooth replacement, with success dependent on osseointegration, implant stability, and bone density. Vitamin D3 plays a critical role in bone metabolism, influencing calcium absorption and bone mineralization. However, the effect of vitamin D3 supplementation on implant outcomes remains controversial. Materials and Methods: A total of 20 patients with vitamin D deficiency (10-30 ng/mL) were divided into two groups: All patients underwent standard implant placement. Crestal bone level and bone density were assessed using CBCT, and implant stability was measured using resonance frequency analysis (RFA) at baseline, 3 months, and 6 months postimplant placement. Data were analyzed using ANOVA ( P < 0.05). Results: Implant stability improved significantly in Group A compared with Group B at 3 and 6 months ( P < 0.05). Crestal bone loss was higher in Group B, but the difference was not statistically significant ( P = 0.07). Bone density remained comparable between both groups at all time points ( P = 1.00). Conclusion: Vitamin D3 supplementation significantly enhances implant stability, suggesting a role in improving early-stage osseointegration. However, its effect on crestal bone level and bone density remains inconclusive. Preoperative vitamin D3 screening and supplementation in deficient individuals may optimize implant outcomes. Further large-scale studies are needed to establish definitive guidelines.

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Publication Details

Journal
Journal of Pharmacy And Bioallied Sciences
Published
2025-10-29
DOI
https://doi.org/10.4103/jpbs.jpbs_649_25
Primary Topic
Vitamin D Research Studies
Type
article
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article

Effect of Vitamin D3 Supplements in the Success of Dental Implants: A Comparative Evaluation

Gudikandula Krishna, Jyothirmai Nagisetty, Deepthi Batthula, Nooka Surya Ramalakshmi et al.
Journal of Pharmacy And Bioallied Sciences
Vitamin D Research Studies
article

Effect of Vitamin D3 Supplements in the Success of Dental Implants: A Comparative Evaluation

Gudikandula Krishna, Jyothirmai Nagisetty, Deepthi Batthula, Nooka Surya Ramalakshmi, D. Samyuktha, Jahnavi Valiveti
article en

Abstract

Background: Dental implants are a reliable treatment for tooth replacement, with success dependent on osseointegration, implant stability, and bone density. Vitamin D3 plays a critical role in bone metabolism, influencing calcium absorption and bone mineralization. However, the effect of vitamin D3 supplementation on implant outcomes remains controversial. Materials and Methods: A total of 20 patients with vitamin D deficiency (10-30 ng/mL) were divided into two groups: All patients underwent standard implant placement. Crestal bone level and bone density were assessed using CBCT, and implant stability was measured using resonance frequency analysis (RFA) at baseline, 3 months, and 6 months postimplant placement. Data were analyzed using ANOVA ( P < 0.05). Results: Implant stability improved significantly in Group A compared with Group B at 3 and 6 months ( P < 0.05). Crestal bone loss was higher in Group B, but the difference was not statistically significant ( P = 0.07). Bone density remained comparable between both groups at all time points ( P = 1.00). Conclusion: Vitamin D3 supplementation significantly enhances implant stability, suggesting a role in improving early-stage osseointegration. However, its effect on crestal bone level and bone density remains inconclusive. Preoperative vitamin D3 screening and supplementation in deficient individuals may optimize implant outcomes. Further large-scale studies are needed to establish definitive guidelines.

Journal of Pharmacy And Bioallied SciencesVol. 18(2)
Kamineni Institute of Dental Sciences (IN)
Openalex Percentile: Top 56%
Vitamin D Research Studies
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