Short-chain fatty acids attenuate sepsis-induced gut dysbiosis and hippocampal neuroinflammation via NLRP6 inflammasome activation in mice
Sepsis disrupts the gut-brain axis by impairing intestinal barrier integrity and NLRP6 inflammasome function, exacerbating hippocampal neuroinflammation. SCFAs mitigate these effects via NLRP6-dependent mechanisms, highlighting their therapeutic potential for SAE. This study provides the first evidence linking SCFA-mediated NLRP6 activation to neuroprotection in sepsis, offering novel insights for targeting the gut microbiota in critical care.
Authors
- Nuobei Zhang
- Zhiwen Ye (ORCID: https://orcid.org/0000-0003-4311-1037)
- Lianwu Zhao (ORCID: https://orcid.org/0000-0003-0055-9720)
- Yan Hong Huang (ORCID: https://orcid.org/0000-0001-5281-0783)
- Chenglong Ge (ORCID: https://orcid.org/0009-0004-8444-1256)
- Wei Chen (ORCID: https://orcid.org/0000-0002-2139-1368)
- Zhili Wen (ORCID: https://orcid.org/0000-0001-5797-9588)
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- He Eye Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1097/js9.0000000000003554
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81