Efficient Synthesis of Amides through Thioacids Reactions with In Situ Generated Formamidine

A formamidine intermediate generated in situ was used as the nitrogen source in a reaction with thioacids to obtain amides. The synthetic protocol described in this paper can be used in the generation of various primary, secondary, and tertiary amides with organic thioacids used as substrates under the optimized conditions. Notably, this protocol uses readily available materials, is nearly solvent-free, supports gram-scale synthesis, and yields structurally diverse amide products with favorable efficiency.