Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration
In general, EVEP mitigates ischemia-related damage and facilitates ex vivo induction of WD, a critical prerequisite for nerve regeneration, functional recovery, and prevention of neuroma formation with subsequent phantom pain, by establishing the pro-regenerative environment for WD, which is further amplified by omitting the anti-inflammatory methylprednisolone.
Authors
- Svenja Kankowski (ORCID: https://orcid.org/0000-0003-0387-3184)
- Arjang Ruhparwar (ORCID: https://orcid.org/0000-0003-2725-9912)
- Bettina Wiegmann (ORCID: https://orcid.org/0000-0001-6556-4059)
- Christine S. Falk (ORCID: https://orcid.org/0000-0003-1376-7318)
- Katherina Katsirntaki
- Danny Jonigk (ORCID: https://orcid.org/0000-0002-5251-2281)
- Kirsten Haastert‐Talini (ORCID: https://orcid.org/0000-0003-2502-8969)
- Falk von Lübken (ORCID: https://orcid.org/0000-0001-7723-9261)
- Christopher Werlein (ORCID: https://orcid.org/0000-0002-7694-4257)
- Alexander Kaltenborn (ORCID: https://orcid.org/0000-0001-5885-0786)
Institutions
- Medizinische Hochschule Hannover (DE)
- International Neuroscience Institute (DE)
- Armed Forces Hospital (SA)
- German Center for Lung Research (DE)
- Hannover Re (Germany) (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s40779-025-00656-6
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00