Pharmacological Management of Post-Traumatic Stress Disorder; A Qualitative Analysis of ClinicalTrials.gov

This is the first qualitative synthesis of phase 4 PTSD pharmacotherapy trials registered on ClinicalTrials.gov, highlighting real-world safety and long-term tolerability gaps that are not analysed in earlier phase studies. The study concluded that the reliance on SSRIs and the growing exploration of novel pharmacological targets in PTSD. The observed heterogeneity reflects the complexity of the disorder and the fragmented nature of current evidence. Findings emphasize the need for future phase 4 trials with larger sample sizes, standardized outcome measures, and newer pharmacological designs to strengthen the applicability of results to clinical practice.