Polygenic risks and cardiovascular treatment effects in severe mental illness
Our findings underscore the dynamic interplay between genetic risks and treatment effects on cardiovascular outcomes in SMI and warrant careful PRS assessment timing. While the clinical utility of PRS is still evolving, future research should explore different disorders' subtype-specific genetic interactions with interventions.
Authors
- Alexandra Burton (ORCID: https://orcid.org/0000-0002-4433-3902)
- David Osborn (ORCID: https://orcid.org/0000-0003-2519-1539)
- Samira Heinkel (ORCID: https://orcid.org/0000-0003-4477-3681)
- Nicholas Bass (ORCID: https://orcid.org/0000-0002-4481-778X)
- Andrew McQuillin (ORCID: https://orcid.org/0000-0003-1567-2240)
- Kai Yao (ORCID: https://orcid.org/0009-0006-0549-3715)
Institutions
- Faculty (United Kingdom) (GB)
- University College London (GB)
Publication Details
- Journal
- Psychiatric Genetics
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1097/ypg.0000000000000401
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00