Bone regeneration during osteoporosis: a translational in vivo monitoring of callus mechanical parameters
Osteoporosis led to a 50% reduction in the viscoelastic response of the distraction callus, likely due to an impaired osteoblastic matrix synthesis. Furthermore, osteoporotic patients undergoing distraction osteogenesis for critical-size defects may experience delayed consolidation with heterogeneous mineralization, which may be linked to early deficits in organic matrix formation.
Authors
- Manuel Sánchez-Raya (ORCID: https://orcid.org/0000-0001-6883-4317)
- Jaime Domínguez (ORCID: https://orcid.org/0000-0002-0491-7911)
- Esther Reina-Romo (ORCID: https://orcid.org/0000-0002-5714-465X)
- Juan Mora‐Macías (ORCID: https://orcid.org/0000-0002-7997-9789)
- Juán Morgaz
- J. Galán (ORCID: https://orcid.org/0000-0003-1304-8372)
- Pablo Blázquez-Carmona (ORCID: https://orcid.org/0000-0002-7605-5812)
- M.M. Granados
- Juan J. Toscano-Angulo (ORCID: https://orcid.org/0000-0001-7946-2408)
Institutions
- Universidad de Cádiz (ES)
- University of Córdoba (ES)
- Universidad de Huelva (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fbioe.2025.1646500
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Regional Development Fund
- Agencia Estatal de Investigación