MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: an exploratory study

Subregion-based MRI radiomics enables accurate, noninvasive prediction of T790M mutations in NSCLC spinal metastases. This subregion-based MRI radiomics model, to our knowledge, is the first to non-invasively predict T790M resistance mutations in spinal metastases by integrating spatial heterogeneity and SHAP interpretability. This subregion-based MRI radiomics model is exploratory and showed a consistent trend toward improved discrimination and net benefit.