A spatially resolved single-cell landscape of colorectal cancer liver metastasis reveals a stromal-tumor glycolytic signaling interaction
We unveil a spatially organized metabolic niche driven by stromal-tumor HGF-MET-MYC signaling. These findings offer novel insights into the stromal-tumor interaction and suggest actionable targets for therapeutic intervention in CRC.
Authors
- Guoxian Guan (ORCID: https://orcid.org/0000-0001-9883-3139)
- Zukai Wang
- Jiahui Chen (ORCID: https://orcid.org/0000-0001-5416-6231)
- Biao Zhu (ORCID: https://orcid.org/0000-0002-5041-9630)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fcell.2025.1687485
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.05