Deficits in medial prefrontal cortex parvalbumin expression and distraction-dependent memory in rats and mice in the sub-chronic phencyclidine model for schizophrenia
These results extend the cross-species validity of the scPCP model in rodents. scPCP-induced susceptibility to distraction in mice is broadly comparable to that observed in scPCP rats and is conserved across object and social memory domains. These behavioral effects correlate with scPCP-induced decreases in PV expression in both species, further implicating altered mPFC excitatory-inhibitory balance in CIAS induction.
Authors
- Ben Grayson (ORCID: https://orcid.org/0000-0001-6843-898X)
- Neveen Mansour (ORCID: https://orcid.org/0000-0002-6666-3742)
- Rasmus S. Petersen (ORCID: https://orcid.org/0000-0002-5607-977X)
- Jennifer Fletcher (ORCID: https://orcid.org/0000-0003-0949-4484)
- John Gigg (ORCID: https://orcid.org/0000-0001-8253-1582)
- Katie Landreth (ORCID: https://orcid.org/0000-0003-3153-8885)
- Michael Harte (ORCID: https://orcid.org/0000-0002-4702-4785)
- Patricia Radu
- Jacob Juty
- Imane Benalla
Institutions
- University of Manchester (GB)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fncel.2025.1669050
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Directorate for Biological Sciences