Gene expression profile in colon cancer therapeutic resistance and its relationship with the tumor microenvironment
The gene expression signature suggests the presence of differentially expressed synaptic membrane genes, which may be involved in neuronal pathways that influence the tumor microenvironment, potentially serving as future biomarkers. Furthermore, the presence of M0 and M2 macrophages and T CD4 memory resting cells suggests a potential interaction that may play a role in therapeutic resistance.
Authors
- Mariana Araújo-Pereira (ORCID: https://orcid.org/0000-0003-4137-9793)
- Vanessa Dybal Bertoni
- Gisele Vieira Rocha (ORCID: https://orcid.org/0000-0001-6437-4536)
- Phillipe Bauer de Araújo Dória (ORCID: https://orcid.org/0000-0002-9796-0942)
- Roberto de Souza Batista dos Santos
- Clarissa Araújo Silva Gurgel
Institutions
- Universidade Federal da Bahia (BR)
- D’Or Institute for Research and Education (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fbinf.2025.1674179
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto D'Or de Pesquisa e Ensino
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Oswaldo Cruz