Liver involvement in Gaucher disease type I: a retrospective single-center study from Ukraine
Liver involvement in GD type I is common, multifaceted, and may not always be reflected in standard liver function tests. While hepatocellular function is typically preserved, structural liver abnormalities are frequently observed. Serum ferritin may serve as an auxiliary marker of disease activity. The results emphasize the need for comprehensive hepatic monitoring in GD and support the potential value of neonatal screening for early detection and management.
Authors
- Н. Г. Горовенко (ORCID: https://orcid.org/0000-0003-4227-7166)
- О.M. Okhotnikova (ORCID: https://orcid.org/0000-0003-2498-0560)
- Nataliia Samonenko (ORCID: https://orcid.org/0000-0002-6927-3301)
- N. V. Olkhovych (ORCID: https://orcid.org/0000-0001-6468-2782)
Institutions
- Shupyk National Healthcare University of Ukraine (UA)
- Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine (UA)
- Children's Specialized Hospital (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fmed.2025.1610755
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00