Single-cell/spatial integration reveals an MES2-like glioblastoma program orchestrated by immune communication and regulatory networks
MES2-like GBM is an ECM-driven, stress-adapted state with strong prognostic impact. We nominate CEBPD and TNFRSF1A/ITGB1 as actionable nodes and identify ARRDC3 as a spatially restricted effector with context-dependent tumor-modulatory functions warranting therapeutic exploration.
Authors
- Jinpeng Wu (ORCID: https://orcid.org/0009-0009-8783-1723)
- Jianguo Wan (ORCID: https://orcid.org/0000-0003-1321-7930)
- Ke‐wei Zheng (ORCID: https://orcid.org/0000-0002-4110-4776)
- Chonghui Zhang (ORCID: https://orcid.org/0000-0002-7077-4795)
- Yugong Feng (ORCID: https://orcid.org/0000-0002-2707-1752)
- Chao Wang (ORCID: https://orcid.org/0000-0001-7928-2634)
- Yifan Xu (ORCID: https://orcid.org/0009-0003-4239-2145)
- T. Lu (ORCID: https://orcid.org/0000-0002-5577-3057)
- Guo Pin
Institutions
- Qingdao University (CN)
- Soochow University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1699134
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25