Pharmacokinetic variability of vancomycin in patients undergoing hematopoietic stem cell transplantation: a retrospective cohort study in Peru
Most post-HSCT patients had subtherapeutic vancomycin levels at the beginning of treatment, which were optimized through individualized adjustments. The pharmacokinetic variability associated with ARC in young patients and those with sepsis supports the use of AUC-based therapeutic drug monitoring over trough concentration monitoring. These findings also highlight the importance of early renal function monitoring in patients treated with HSCT.
Authors
- Alfredo Wong-Chang (ORCID: https://orcid.org/0000-0001-8257-4320)
- Cesar Copaja‐Corzo (ORCID: https://orcid.org/0000-0002-3497-0158)
- Liz Aliaga-Tabraj (ORCID: https://orcid.org/0000-0002-0731-3996)
- Wilder Bolaños-Vargas (ORCID: https://orcid.org/0009-0005-4561-9549)
- Karel Santamaria-Leandro
- Manuel Fernandez-Puycan
- Arturo Yoshimar Luque-Mamani
Institutions
- Universidad de Lima (PE)
- Universidad San Ignacio de Loyola (PE)
- Hospital Nacional Cayetano Heredia (PE)
- Fondazione Stella Maris (IT)
- St Martins Hospital (GB)
Publication Details
- Journal
- Therapeutic Advances in Drug Safety
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/20420986251384239
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00