Rosuvastatin for intracranial aneurysms treated with flow diverters: preclinical study in rabbits

In rabbit FD models, rosuvastatin therapy seems to improve aneurysm occlusion, preserving side branch patency. We also found an association between drug levels and endothelial cells covering the FD. These findings support further investigations.

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Publication Details

Journal
Journal of NeuroInterventional Surgery
Published
2025-10-28
DOI
https://doi.org/10.1136/jnis-2025-024237
Primary Topic
Intracranial Aneurysms: Treatment and Complications
Type
article
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article

Rosuvastatin for intracranial aneurysms treated with flow diverters: preclinical study in rabbits

Ludovic Micallef, Maxime Baudouin, Nicolas Dubois, Aymeric Rouchaud et al.
Journal of NeuroInterventional Surgery
Intracranial Aneurysms: Treatment and Complications
article

Rosuvastatin for intracranial aneurysms treated with flow diverters: preclinical study in rabbits

Ludovic Micallef, Maxime Baudouin, Nicolas Dubois, Aymeric Rouchaud, Michele Romoli, Alexis Belgacem, Nicolas Picard, Faraj Terro, Charbel Mounayer, Jonathan Cortese, Sylvia M. Bardet, Jérémy Mounier, M Coulomb, Romain Chauvet, Francesco Diana, Aurélien Le Flahec, Francesco Di Salle, Sylvain Dulaurent, Géraud Forestier, Édouard Lefebvre, Daphnée Chandellier, Gregory Sasselina, Claude Couquet, Marie Laure Perrin, M. D’Arrigo, Caroline Croguennec, Heloise Daverat, Voahirana Ratsimnazafy
article en

Abstract

In rabbit FD models, rosuvastatin therapy seems to improve aneurysm occlusion, preserving side branch patency. We also found an association between drug levels and endothelial cells covering the FD. These findings support further investigations.

Journal of NeuroInterventional Surgery
Hebron University (PS), Centre National de la Recherche Scientifique (FR), University of Salerno (IT), Inserm (FR), CHI Health (US), Institut de Recherche pour le Développement (CG), Ospedale “M. Bufalini” di Cesena (IT), Centre Hospitalier Universitaire de Limoges (FR), Vall d'Hebron Hospital Universitari (ES), Hôpital Dupuytren (FR), Bicêtre Hospital (FR), Institut de Recherche pour le Développement (FR), Link Campus University (IT), Université de Limoges (FR)
Openalex Percentile: Top 56%
Intracranial Aneurysms: Treatment and Complications
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