METTL3/IGF2BP2-Mediated m6A RNA Methylation Drives Alveolar Macrophage-Dependent Neutrophil Recruitment in Cigarette Smoke-Induced COPD
Our results uncover a novel epitranscriptional pathway through which cigarette smoke promotes neutrophilic inflammation via m<sup>6</sup>A-dependent regulation of both CXCL8 in macrophages and ICAM-1 in endothelial cells. These findings position the METTL3/IGF2BP2/m<sup>6</sup>A axis as a central regulatory mechanism coordinating multicellular interactions in COPD pathogenesis and suggest its potential as a therapeutic target for modulating disease progression.
Authors
- Jian Wang (ORCID: https://orcid.org/0000-0002-8403-3832)
- Aili Lin
- Ya‐Ping Zhang (ORCID: https://orcid.org/0000-0002-5401-1114)
- Lixing Wang
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s532958
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province