<i>APOE</i> ε4 disrupts neuronal and network‐level function in the anterior olfactory nucleus: Influence of age and sex
This is the first study on the interactive impact of three Alzheimer's disease risk factors on anterior olfactory nucleus neural functions. Apolipoprotein E ε4 reduces neuronal excitability regardless of age and sex. Females show higher excitability than males in the adult group but not in aged group. Age increases excitability in a genotype-dependent manner. Network oscillations vary by genotype and sex but are consistently enhanced by age.
Authors
- Çoşar Uzun (ORCID: https://orcid.org/0000-0002-5950-9173)
- Shaolin Liu (ORCID: https://orcid.org/0000-0003-3351-8642)
- Yaping Li (ORCID: https://orcid.org/0000-0002-0574-6966)
Institutions
- University of Georgia (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70865
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46