Plasma proteomic Alzheimer's risk score: Biological age clock and pseudotime trajectory
Plasma proteomic aging clocks and pseudotime provide potential markers for Alzheimer's disease (AD) risk. Cognition-optimized brain aging and pseudotime link to diagnosis and AD biomarkers. Brain aging clock and pseudotime improve the diagnosis classification performance. Pseudotime outperformed established plasma biomarkers for diagnosis classification.
Authors
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Nicholas K. Adzibolosu (ORCID: https://orcid.org/0000-0002-3829-5786)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Tamina Park
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0001-8090-6571)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Soumilee Chaudhuri (ORCID: https://orcid.org/0000-0002-8488-6114)
- Jared R. Brosch (ORCID: https://orcid.org/0000-0002-6578-0584)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Yen‐Ning Huang
- Shiwei Liu
Institutions
- Indiana University School of Medicine
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70851
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00