Human teratozoospermia-related AGTPBP1 R791H mutation is associated with sperm head and tail defects in a CRISPR-engineered murine model
We conclude that the R791H mutation in the Agtpbp1 gene impairs sperm head and tail differentiation, resulting in sperm morphological defects.
Authors
- Chin‐Fong Au (ORCID: https://orcid.org/0000-0002-1402-2070)
- Singh Rajender (ORCID: https://orcid.org/0000-0002-4592-6566)
- Tsung‐Hsuan Lai (ORCID: https://orcid.org/0000-0001-6160-7816)
- Yayun Wang (ORCID: https://orcid.org/0000-0002-0397-0390)
- I‐Shing Yu (ORCID: https://orcid.org/0000-0002-2369-5816)
- Chih‐Chun Ke
- Yu‐Hua Lin (ORCID: https://orcid.org/0000-0002-6284-4968)
- Ying‐Hung Lin (ORCID: https://orcid.org/0000-0002-1574-1579)
Institutions
- Fu Jen Catholic University (TW)
- National Taiwan University (TW)
- Central Drug Research Institute (IN)
- En Chu Kong Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Cathay General Hospital (TW)
- Cardinal Tien Hospital (TW)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1007/s10815-025-03732-x
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cathay General Hospital
- National Taiwan University
- Cardinal Tien Hospital
- National Science and Technology Council