An intracellular transporter mitigates the <scp>CO</scp> <sub>2</sub> ‐induced decline in iron content in <i>Arabidopsis</i> shoots

Rising atmospheric CO<sub>2</sub> negatively affects plant iron (Fe) content, yet the underlying mechanisms remain poorly understood. Here, we identified More Iron under elevated CO<sub>2</sub> (MIC) as a new player involved in Fe homeostasis under elevated CO<sub>2</sub> in Arabidopsis thaliana. MIC is a previously uncharacterized transmembrane protein which we found predominantly localized to the Golgi apparatus. Loss of MIC function results in increased Fe content under elevated CO<sub>2</sub>, effectively mitigating the Fe decline observed in plants. MIC protein abundance is reduced in roots under elevated CO<sub>2</sub>, suggesting post-transcriptional regulation of protein stability. This work identifies MIC as a novel component in the plant response to elevated CO<sub>2</sub>, with potential implications for improving the nutritional quality of crops under climate change.

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Publication Details

Journal
FEBS Letters
Published
2025-10-28
DOI
https://doi.org/10.1002/1873-3468.70202
Primary Topic
Plant responses to elevated CO2
Type
article
Field-Weighted Citation Impact
0.00

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article

An intracellular transporter mitigates the CO 2 ‐induced decline in iron content in Arabidopsis shoots

Laurence Lejay, Antoine Martin, Christian Dubos, Mattia Adamo et al.
FEBS Letters
Plant responses to elevated CO2
article

An intracellular transporter mitigates the CO 2 ‐induced decline in iron content in Arabidopsis shoots

Laurence Lejay, Antoine Martin, Christian Dubos, Mattia Adamo, Matthieu Pierre Platre, Timothy Mozzanino, Cécile Fizames, Meijie Li
article en

Abstract

Rising atmospheric CO<sub>2</sub> negatively affects plant iron (Fe) content, yet the underlying mechanisms remain poorly understood. Here, we identified More Iron under elevated CO<sub>2</sub> (MIC) as a new player involved in Fe homeostasis under elevated CO<sub>2</sub> in Arabidopsis thaliana. MIC is a previously uncharacterized transmembrane protein which we found predominantly localized to the Golgi apparatus. Loss of MIC function results in increased Fe content under elevated CO<sub>2</sub>, effectively mitigating the Fe decline observed in plants. MIC protein abundance is reduced in roots under elevated CO<sub>2</sub>, suggesting post-transcriptional regulation of protein stability. This work identifies MIC as a novel component in the plant response to elevated CO<sub>2</sub>, with potential implications for improving the nutritional quality of crops under climate change.

FEBS LettersVol. 600(4)
Centre National de la Recherche Scientifique (FR), Université de Montpellier (FR), Institut Agro Montpellier (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Institut Agro Montpelier (FR), Institut des Sciences des Plantes de Montpellier (FR)
Agence Nationale de la Recherche, China Scholarship Council, Centre National de la Recherche Scientifique, Région Occitanie Pyrénées-Méditerranée, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Openalex Percentile: Top 77%
Plant responses to elevated CO2
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