Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis
This study suggests that ACPA status may not fully capture the biological heterogeneity between ACPA- and ACPA+ RA subgroups, indicating additional immune and metabolic distinctions that warrant further investigation. Our findings highlight the potential of multi-omic profiling to enhance RA diagnostics, refine disease stratification, and inform subgroup-specific disease management strategies.
Authors
- John M. Davis (ORCID: https://orcid.org/0000-0002-8522-5406)
- Vinod K. Gupta (ORCID: https://orcid.org/0000-0003-1467-9993)
- Elena Myasoedova (ORCID: https://orcid.org/0000-0003-2006-1436)
- Jaeyun Sung (ORCID: https://orcid.org/0000-0002-3005-2798)
- Kenneth J. Warrington (ORCID: https://orcid.org/0000-0001-7708-2487)
- Hu Zeng (ORCID: https://orcid.org/0000-0002-9909-7732)
- Vanessa L. Kronzer (ORCID: https://orcid.org/0000-0002-7489-3134)
- Cynthia S. Crowson (ORCID: https://orcid.org/0000-0001-5847-7475)
- Minsik Oh (ORCID: https://orcid.org/0000-0003-4170-1543)
- Benjamin Hur
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Myongji University (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1667662
- Citations
- 3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.00