The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation
These findings suggest that co-administration of CBD with RES or ALA exerts synergistic antidepressants and anti-aggressive effects in a PTSD-like model, potentially allowing for dose reduction of CBD. Further studies are warranted to explore the underlying molecular mechanisms.
Authors
- Francesca Guida (ORCID: https://orcid.org/0000-0003-0759-9602)
- Roozbe Bonsale (ORCID: https://orcid.org/0009-0007-8718-877X)
- Enza Palazzo
- Michela Perrone (ORCID: https://orcid.org/0000-0002-3284-9944)
- Francesca Gargano (ORCID: https://orcid.org/0000-0002-5415-9776)
- E. Martino (ORCID: https://orcid.org/0009-0007-9761-5501)
- Serena Boccella (ORCID: https://orcid.org/0000-0002-3632-3536)
- Livio Luongo (ORCID: https://orcid.org/0000-0002-1949-2039)
- Carmela Belardo (ORCID: https://orcid.org/0000-0001-7588-462X)
- Sabatino Maione (ORCID: https://orcid.org/0000-0003-3850-6704)
- Maria Consiglia Trotta (ORCID: https://orcid.org/0000-0001-9813-5955)
- Consalvo Mattia (ORCID: https://orcid.org/0000-0003-1894-9575)
- Rosmara Infantino (ORCID: https://orcid.org/0000-0003-1266-6881)
- Fiore Ricciardi
- Monica Iannotta (ORCID: https://orcid.org/0000-0002-2248-8663)
- Antimo Fusco
- Andrea Maria Morace
- Rebecca Limongelli
Institutions
- Università Campus Bio-Medico (IT)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University of Campania "Luigi Vanvitelli" (IT)
- University Hospital Galway (IE)
- Link Campus University (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fphar.2025.1676421
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00