Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database

This study represents the first FAERS-based assessment of ADE risk differences between Nivolumab and Cetuximab in HNC, offering valuable evidence for clinical monitoring and drug selection. As signal detection reflects statistical correlation rather than causality, confirmatory clinical validation remains necessary. Integration of real-world evidence with prospective clinical trials will be essential to enhance drug safety evaluation systems.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-10-29
DOI
https://doi.org/10.3389/fimmu.2025.1658535
Citations
1
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
1.85

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article

Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database

Yi Tang, Yibo Zhou, Yongchuan She, Danping Chen et al.
1 citations
Frontiers in Immunology
Head and Neck Cancer Studies
1.85
article

Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database

Yi Tang, Yibo Zhou, Yongchuan She, Danping Chen, Ren Yu, Zhihang Chen, Zhai Liu, Jun Wan
article en
1 citations

Abstract

This study represents the first FAERS-based assessment of ADE risk differences between Nivolumab and Cetuximab in HNC, offering valuable evidence for clinical monitoring and drug selection. As signal detection reflects statistical correlation rather than causality, confirmatory clinical validation remains necessary. Integration of real-world evidence with prospective clinical trials will be essential to enhance drug safety evaluation systems.

Frontiers in ImmunologyVol. 16
Changsha Central Hospital (CN), Changsha Hospital for Maternal and Child Health Care (CN), The Eighth Hospital of Xi'an (CN)
Hunan University, Natural Science Foundation of Hunan Province, Science and Technology Bureau, Changsha, Hunan University of Chinese Medicine
Openalex Percentile: Top 11%
Head and Neck Cancer Studies
1.85
DOIOpen Access PDFOpenAlex
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Signal mining and analysis of influencing factors for adverse events of Nivolumab and Cetuximab in the treatment of head and neck cancer based on the US FAERS database — Yi Tang, Yibo Zhou, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS