Clinical validation of comprehensive time- and frequency-domain photoplethysmography features from a single-sensor system for non-invasive assessment of vascular load and systolic blood pressure

Our results demonstrate the promise of a single-sensor PPG-based approach for monitoring hypertension-related, subtle vascular alterations by combining morphological and spectral information. Progressive decline in harmonic ratios provides new information on arterial stiffening and changed wave reflections. This level of physiological depth combined with a remarkably simple and portable approach is the key that could allow wearable devices to provide immediate blood pressure screening for unprecedented widespread user engagement. These aspects are facilitated by making the test easier to operate than standard PCR and combining it with types of analyte detection that expand its performance capabilities in this specific disease context.