Integration of bulk and single-cell transcriptomic data reveals a novel signature related to liver metastasis and basement membrane in pancreatic cancer
This study developed and rigorously validated an innovative prognostic model for PC. This model, incorporating pivotal genes of PCLM and BM, may also serve as potential tool for predicting the tumor immune microenvironment and therapeutic efficacy. Notably, COL7A1, which was demonstrated to be vital in PC metastasis in this study, warrants further investigation in future research.
Authors
- Bijun Cui
- Dongkai Zhou (ORCID: https://orcid.org/0000-0003-0705-9796)
- Qifan Yang (ORCID: https://orcid.org/0000-0002-8300-3869)
- Yizhi Wang (ORCID: https://orcid.org/0009-0008-1449-8424)
- Cheng Zhong (ORCID: https://orcid.org/0000-0002-7756-9313)
Institutions
- Blood Center of Zhejiang Province (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1671956
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00