Atorvastatin Alleviates Sepsis-Induced Cardiomyopathy by Targeting the METTL3/IGF2BP1/CXCL2 Pathway
This study elucidates that the METTL3 (m<sup>6</sup>A)/IGF2BP1/CXCL2 axis promotes the pathological progression of SICM, and ATO exerts cardioprotective effects by targeting this pathway, providing new insights into the significance of RNA m<sup>6</sup>A modification in SICM.
Authors
- Fei Mu (ORCID: https://orcid.org/0000-0001-5706-8864)
- Feihong Jin (ORCID: https://orcid.org/0000-0002-9403-4169)
- Lingling Zheng (ORCID: https://orcid.org/0000-0001-7333-2768)
- Yiwen Wang (ORCID: https://orcid.org/0000-0003-2069-6685)
- Jingwen Wang (ORCID: https://orcid.org/0000-0002-3450-9046)
- Yanping Yin
- Lulu Zhang (ORCID: https://orcid.org/0000-0001-9337-9395)
- Jinyi Zhao
- Rui Gong (ORCID: https://orcid.org/0009-0005-3690-3249)
Institutions
- Northwest University (CN)
- Xijing Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s532987
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81