GNPNAT1 acts as a prognostic biomarker associated with immune infiltration in lung adenocarcinoma and promotes the proliferation and invasion of cancer cells
GNPNAT1 is overexpressed in lung adenocarcinoma and serves as an adverse prognostic biomarker. Its modulation of immune cell infiltration and engagement of the ERK/MAPK signaling cascade underscores its potential as both a prognostic indicator and therapeutic target in LUAD.
Authors
- Meigui You
- Y. Tang (ORCID: https://orcid.org/0000-0002-2373-4184)
- Yujuan Tang
- Hongmiao Wang (ORCID: https://orcid.org/0000-0001-8558-6597)
- Yaping Xu (ORCID: https://orcid.org/0000-0001-6293-4384)
- Qingfeng Li (ORCID: https://orcid.org/0000-0002-3603-7580)
- Jingyi Li (ORCID: https://orcid.org/0000-0001-8048-7207)
- Qing Lan (ORCID: https://orcid.org/0000-0002-0888-8839)
- Yi Xue (ORCID: https://orcid.org/0009-0006-8614-1913)
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Xiamen Medical College
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1007/s12672-025-03818-z
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province