<i>In vitro</i> assessment of P-glycoprotein-mediated antiseizure medications efflux in a blood–brain barrier cell model
The findings support that valproic acid and lamotrigine are likely substrates of P-gp at the BBB. Thus, targeting the P-gp-mediated efflux may represent a promising strategy for managing drug-resistant epilepsy against these ASMs.
Authors
- Priyanka Rani Paul (ORCID: https://orcid.org/0000-0001-5214-2770)
- Samiksha Kukal
- Ritushree Kukreti (ORCID: https://orcid.org/0000-0002-6968-1129)
- Ankit Srivastava (ORCID: https://orcid.org/0000-0003-2076-879X)
- Shivangi Bora (ORCID: https://orcid.org/0000-0002-6436-4095)
- Manish Mishra (ORCID: https://orcid.org/0009-0004-1588-2904)
Institutions
- Institute of Genomics and Integrative Biology (IN)
- Jamia Hamdard (IN)
- Council of Scientific and Industrial Research (IN)
- Delhi Technological University (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.1093/jpp/rgaf099
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00