Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer
Our study introduces a novel rational combination therapy in PDAC. Dual targeting of PI3Kα/δ and SUMO signaling bears potential for clinical translation.
Authors
- Constanza Tapia Contreras (ORCID: https://orcid.org/0000-0003-2054-0963)
- Jens Hoffmann (ORCID: https://orcid.org/0000-0003-3880-1658)
- Michael B. Ghadimi (ORCID: https://orcid.org/0000-0001-8208-1526)
- Matthias Wirth (ORCID: https://orcid.org/0000-0002-8340-0872)
- Hazal Köse (ORCID: https://orcid.org/0000-0003-4307-5654)
- Kai Kappert (ORCID: https://orcid.org/0000-0001-6976-0428)
- Philipp Mertins (ORCID: https://orcid.org/0000-0002-2245-528X)
- Ulrich Bernd Keller (ORCID: https://orcid.org/0000-0002-8485-1958)
- Christian Schneeweis
- Marieluise Kirchner (ORCID: https://orcid.org/0000-0002-7049-534X)
- Zuzana Tatárová (ORCID: https://orcid.org/0000-0002-3128-7214)
- Juraj Jakubík
- Frederik Herzberg (ORCID: https://orcid.org/0000-0001-6185-223X)
- Elisabeth Heßmann (ORCID: https://orcid.org/0000-0002-9462-1291)
- Simone Rhein (ORCID: https://orcid.org/0000-0002-9445-2352)
- Uta M. Demel (ORCID: https://orcid.org/0000-0002-6480-4185)
- Günter Schneider (ORCID: https://orcid.org/0000-0003-1840-4508)
- Dieter Saur (ORCID: https://orcid.org/0000-0001-5874-0210)
- Leonie Witte (ORCID: https://orcid.org/0000-0003-2154-937X)
- Jovan Todorović
- Sebastian Ebert
- Chuanbing Zang
- Leoni Moldaner
- Isabelle Träger
- Philipp Putze
- Laura Ferreiro
- Ilaria Deidda
Institutions
- German Cancer Research Center (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsmedizin Göttingen (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- BioTez (Germany) (DE)
- Georg Speyer Haus (DE)
- Helios Hospital Berlin-Buch (DE)
- Frankfurt Cancer Institute (DE)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1053/j.gastro.2025.08.018
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universitätsmedizin Göttingen
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Deutschen Konsortium für Translationale Krebsforschung
- Stiftung Charité