Early versus adult onset of schizophrenia: an examination of premorbid and current IQ

EOS had lower current IQ than AOS, but did not differ in premorbid IQ, suggesting a larger decline from premorbid IQ levels. This could imply different neurodevelopmental processes underlying cognitive dysfunction related to age of onset in schizophrenia, underscoring the necessity for further inquiry into the mechanisms driving this decline and strategies for its prevention.

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Publication Details

Journal
Schizophrenia Research Cognition
Published
2025-10-15
DOI
https://doi.org/10.1016/j.scog.2025.100397
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00

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Early versus adult onset of schizophrenia: an examination of premorbid and current IQ

Dimitrios Andreou, Erik G. Jönsson, Tereza Calkova, Nils Eiel Steen et al.
Schizophrenia Research Cognition
Schizophrenia research and treatment
article

Early versus adult onset of schizophrenia: an examination of premorbid and current IQ

Dimitrios Andreou, Erik G. Jönsson, Tereza Calkova, Nils Eiel Steen, Kjetil Nordbø Jørgensen, Ingrid Agartz, Runar Elle Smelror, Karin Collste, Ole A. Andreassen, Christine Mohn, Ingrid Melle, Torill Ueland, Laura A. Wortinger, Beathe Haatveit, Simon Červenka, Anne M. Myhre, Anja Vaskinn, Lynn Mørch-Johnsen
article en

Abstract

EOS had lower current IQ than AOS, but did not differ in premorbid IQ, suggesting a larger decline from premorbid IQ levels. This could imply different neurodevelopmental processes underlying cognitive dysfunction related to age of onset in schizophrenia, underscoring the necessity for further inquiry into the mechanisms driving this decline and strategies for its prevention.

Schizophrenia Research CognitionVol. 43
Uppsala University (SE), Oslo University Hospital (NO), University of Oslo (NO), Vestre Viken Hospital Trust (NO), Karolinska Institutet (SE), Västmanlands sjukhus Västerås (SE), Precision for Medicine (United States) (US), Diakonhjemmet Hospital (NO), Mälardalen University (SE), Stockholm Health Care Services (SE), Østfold Hospital Trust (NO)
Norges Forskningsråd, Helse Sør-Øst RHF
Openalex Percentile: Top 63%
Schizophrenia research and treatment
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