<i>USP25</i> in genetic generalized epilepsy: a gene under scrutiny

Authors

Orrin Devinsky (ORCID: https://orcid.org/0000-0003-0044-4632)
Ganna Balagura (ORCID: https://orcid.org/0000-0003-0212-8318)
Savvas Papacostas (ORCID: https://orcid.org/0000-0003-3845-7439)
Christoph J. Schankin (ORCID: https://orcid.org/0000-0003-4668-6098)
Zaid Afawi (ORCID: https://orcid.org/0000-0002-1121-9513)
Manuela Pendziwiat (ORCID: https://orcid.org/0000-0001-8942-8334)
Lorenzo Muccioli (ORCID: https://orcid.org/0000-0001-6827-0099)
Wassim Nasreddine (ORCID: https://orcid.org/0000-0001-6487-8259)
Karl Martin Klein (ORCID: https://orcid.org/0000-0002-6654-1665)
Seo‐Kyung Chung (ORCID: https://orcid.org/0000-0002-5008-8384)
Felecia Cerrato (ORCID: https://orcid.org/0000-0002-9086-7710)
Sarah Weckhuysen (ORCID: https://orcid.org/0000-0003-2878-1147)
Renzo Guerrini (ORCID: https://orcid.org/0000-0002-7272-7079)
Enrique Rojas (ORCID: https://orcid.org/0000-0003-3388-2794)
J Gordon Millichap (ORCID: https://orcid.org/0000-0002-0798-0131)
Calwing Liao (ORCID: https://orcid.org/0000-0001-6169-7137)
Hiltrud Muhle
Elena Parrini (ORCID: https://orcid.org/0000-0001-8933-7694)
Stephanie L. Leech
Jill R. Murrell (ORCID: https://orcid.org/0000-0002-1885-8385)
Algirdas Utkus (ORCID: https://orcid.org/0000-0001-5766-6653)
Francesca Ragona (ORCID: https://orcid.org/0000-0003-1399-8271)
Charles R. Newton (ORCID: https://orcid.org/0000-0002-6999-5507)
Alica M. Goldman (ORCID: https://orcid.org/0000-0002-5491-5746)
Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
Benjamin M. Neale (ORCID: https://orcid.org/0000-0003-1513-6077)
Susanne Knake (ORCID: https://orcid.org/0000-0002-6298-0513)
Francesco Fortunato (ORCID: https://orcid.org/0000-0001-8395-7809)
Christopher M. McGraw (ORCID: https://orcid.org/0000-0002-5460-4550)
Grazia Annesi (ORCID: https://orcid.org/0000-0001-9951-8798)
George A. Tanteles (ORCID: https://orcid.org/0000-0002-8117-9852)
Susanne Schubert‐Bast (ORCID: https://orcid.org/0000-0003-1545-7364)
Lara E. Jehi (ORCID: https://orcid.org/0000-0002-8041-6377)
Biruté Tumiene (ORCID: https://orcid.org/0000-0001-6010-2584)
Sylvain Rheims (ORCID: https://orcid.org/0000-0002-4663-8515)
Annapurna Poduri (ORCID: https://orcid.org/0000-0002-7350-5136)
Elisabetta Amadori (ORCID: https://orcid.org/0000-0003-0935-7404)
Samuel Wiebe (ORCID: https://orcid.org/0000-0002-1061-9099)
Reetta Kälviäinen (ORCID: https://orcid.org/0000-0003-2935-5131)
Thomas N. Ferraro (ORCID: https://orcid.org/0000-0003-2250-8772)
Randi von Wrede (ORCID: https://orcid.org/0000-0002-9430-5037)
Erin L. Heinzen (ORCID: https://orcid.org/0000-0002-7268-8559)
Caitlin A. Bennett (ORCID: https://orcid.org/0000-0002-9109-1483)
Toshimitsu Suzuki (ORCID: https://orcid.org/0000-0003-0585-5692)
Henrike Heyne (ORCID: https://orcid.org/0000-0001-9893-3850)
Laura Canafoglia (ORCID: https://orcid.org/0000-0002-5385-761X)
Holger Lerche (ORCID: https://orcid.org/0000-0002-1783-8710)
Heinz Krestel (ORCID: https://orcid.org/0000-0001-8742-0232)
Ioanna Kousiappa (ORCID: https://orcid.org/0000-0002-7491-5946)
William Owen Pickrell (ORCID: https://orcid.org/0000-0003-4396-5657)
Dennis Dlugos (ORCID: https://orcid.org/0000-0003-3088-7645)
Jacqueline A. French (ORCID: https://orcid.org/0000-0003-2242-8027)
Danielle Molinari Andrade (ORCID: https://orcid.org/0000-0003-0953-2698)
Russell J. Buono (ORCID: https://orcid.org/0000-0003-3799-4355)
Felix Zahnert (ORCID: https://orcid.org/0000-0003-0366-6724)
Gábor Zsurka (ORCID: https://orcid.org/0000-0002-6379-849X)
Ingrid Eileen Scheffer (ORCID: https://orcid.org/0000-0002-2311-2174)
Ulrich Stephani (ORCID: https://orcid.org/0000-0003-0493-7522)
Gianpiero L. Cavalleri (ORCID: https://orcid.org/0000-0002-9802-0506)
Viola Doccini (ORCID: https://orcid.org/0000-0002-5166-8401)
Daniel H. Lowenstein (ORCID: https://orcid.org/0000-0002-9546-2085)
Karen Müller‐Schlüter
Robyn M. Busch (ORCID: https://orcid.org/0000-0002-5442-4912)
Tiziana Granata (ORCID: https://orcid.org/0000-0002-0170-6836)
Ilaria Sammarra (ORCID: https://orcid.org/0000-0003-4136-9245)
Gaëtan Lesca (ORCID: https://orcid.org/0000-0001-7691-9492)
Bernd A. Neubauer (ORCID: https://orcid.org/0000-0002-2975-5007)
Costin Leu (ORCID: https://orcid.org/0000-0003-0598-3301)
Alison Anderson (ORCID: https://orcid.org/0000-0002-1490-2262)
I‐Jun Chou (ORCID: https://orcid.org/0000-0002-5791-3308)
Antonella Riva (ORCID: https://orcid.org/0000-0001-9152-5571)
Barbara Castellotti (ORCID: https://orcid.org/0000-0002-9098-3041)
Chantal Depondt
Meng‐Han Tsai (ORCID: https://orcid.org/0000-0002-4570-5712)
Samuel F. Berkovic (ORCID: https://orcid.org/0000-0003-4580-841X)
Stefania Magri (ORCID: https://orcid.org/0000-0002-9610-7544)
Annika Faucon (ORCID: https://orcid.org/0000-0003-4509-0428)
Francesca Madia (ORCID: https://orcid.org/0000-0002-7807-1322)
Federico Zara (ORCID: https://orcid.org/0000-0001-9744-5222)
Johannes R. Lemke (ORCID: https://orcid.org/0000-0002-4435-6610)
Davide Mei (ORCID: https://orcid.org/0000-0001-6790-6251)
Beth R. Shiedley
Patrick Cossette
Larry Baum (ORCID: https://orcid.org/0000-0002-5345-9355)
Andreas Koupparis (ORCID: https://orcid.org/0000-0002-0737-2347)
Simona Balestrini (ORCID: https://orcid.org/0000-0001-5639-1969)
Mark I. Rees (ORCID: https://orcid.org/0000-0003-3570-5986)
Patrick May (ORCID: https://orcid.org/0000-0001-8698-3770)
Stefan Wolking (ORCID: https://orcid.org/0000-0002-1460-6623)
Mariagrazia Talarico (ORCID: https://orcid.org/0000-0002-7439-3973)
Michael E. Talkowski (ORCID: https://orcid.org/0000-0003-2889-0992)
Roland Krause (ORCID: https://orcid.org/0000-0001-9938-7126)
Luciana Midori Inuzuka (ORCID: https://orcid.org/0000-0001-6840-5918)
Raffaella Minardi (ORCID: https://orcid.org/0000-0002-8190-8517)
Elena Freri (ORCID: https://orcid.org/0000-0002-2293-8687)
Adam Strzelczyk (ORCID: https://orcid.org/0000-0001-6288-9915)
Luc Valton (ORCID: https://orcid.org/0000-0001-6718-8210)
Annalisa Vetro (ORCID: https://orcid.org/0000-0003-2437-7526)
Gerhard Kluger (ORCID: https://orcid.org/0000-0003-1234-994X)
Quratulain Zulfiqar Ali (ORCID: https://orcid.org/0000-0002-3984-5276)
Martha Feucht (ORCID: https://orcid.org/0000-0001-7691-8158)
Paolo Tinuper (ORCID: https://orcid.org/0000-0002-0588-3063)
Monica Gagliardi (ORCID: https://orcid.org/0000-0002-3386-9808)
L.G. Austin (ORCID: https://orcid.org/0000-0003-2980-0354)
Çiğdem Özkara (ORCID: https://orcid.org/0000-0003-0548-1838)
Ryan G. Wagner (ORCID: https://orcid.org/0000-0003-2741-3676)
Martin Krenn (ORCID: https://orcid.org/0000-0003-3026-3082)
Sanjay M. Sisodiya (ORCID: https://orcid.org/0000-0002-1511-5893)
Mark P. Fitzgerald (ORCID: https://orcid.org/0000-0002-7121-0705)
Andrew J. Cole (ORCID: https://orcid.org/0000-0002-0828-826X)
Leon G. Epstein (ORCID: https://orcid.org/0000-0003-4264-3867)
Carmen Barba (ORCID: https://orcid.org/0000-0001-5445-5842)
Angelo Labate (ORCID: https://orcid.org/0000-0002-8827-7324)
Lisa Ferguson
Symon M. Kariuki (ORCID: https://orcid.org/0000-0002-3934-5132)
Charlotte Lawthom (ORCID: https://orcid.org/0000-0003-1774-6506)
Yvonne Weber (ORCID: https://orcid.org/0000-0002-0806-5592)
Andreas van Baalen (ORCID: https://orcid.org/0000-0001-7988-5224)
Rainer Surges (ORCID: https://orcid.org/0000-0002-3177-8582)
Andreas Schulze‐Bonhage (ORCID: https://orcid.org/0000-0003-2382-0506)
Ahmad Beydoun (ORCID: https://orcid.org/0000-0002-9047-1185)
Laura Licchetta (ORCID: https://orcid.org/0000-0001-7979-9895)
Pınar Topaloğlu
Betül Baykan (ORCID: https://orcid.org/0000-0002-3360-659X)
Tobias Baumgartner (ORCID: https://orcid.org/0000-0001-5935-9841)
Kevin Haas
Zühal Yapıcı (ORCID: https://orcid.org/0000-0002-9349-565X)
Christian M. Boßelmann (ORCID: https://orcid.org/0000-0002-1596-5599)
Dalila Pinto (ORCID: https://orcid.org/0000-0002-8769-0846)
Marian Todaro (ORCID: https://orcid.org/0000-0003-0190-5760)
Siwei Chen (ORCID: https://orcid.org/0000-0003-1942-7381)
Chris Cotsapas (ORCID: https://orcid.org/0000-0002-7772-5910)
David B. Goldstein (ORCID: https://orcid.org/0000-0001-7627-0259)
David Lewis‐Smith (ORCID: https://orcid.org/0000-0002-1735-8178)
Ingo Helbig (ORCID: https://orcid.org/0000-0001-8486-0558)
Olivia Hoeper
Colin A. Ellis
Francesca Bisulli
Kathryn R. Sparks
Felicitas Becker
Gerhard Kurlemann
Jean Khoury (ORCID: https://orcid.org/0000-0001-5334-2942)
Ingo Borggräfe
Dilşad Türkdoğan
Meghan Evans
Anna J. Prentice
Maryam Erfanian Omidvar (ORCID: https://orcid.org/0000-0002-9808-0197)

Institutions

Children's Hospital of Philadelphia (US)
University of Luxembourg (LU)
Christian-Albrechts-Universität zu Kiel (DE)
Hertie Institute for Clinical Brain Research (DE)
University of Pennsylvania (US)
University of Tübingen (DE)

Publication Details

Journal: Brain
Published: 2025-10-25
DOI: https://doi.org/10.1093/brain/awaf406
Citations: 1
Primary Topic: Ubiquitin and proteasome pathways
Type: article
Field-Weighted Citation Impact: 0.81

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article

USP25 in genetic generalized epilepsy: a gene under scrutiny

Orrin Devinsky, Ganna Balagura, Savvas Papacostas, Christoph J. Schankin et al.

Oct 25, 2025

1 citations

Brain

Ubiquitin and proteasome pathways

0.81

article

USP25 in genetic generalized epilepsy: a gene under scrutiny

Orrin Devinsky, Ganna Balagura, Savvas Papacostas, Christoph J. Schankin, Zaid Afawi, Manuela Pendziwiat, Lorenzo Muccioli, Wassim Nasreddine, Karl Martin Klein, Seo‐Kyung Chung, Felecia Cerrato, Sarah Weckhuysen, Renzo Guerrini, Enrique Rojas, J Gordon Millichap, Calwing Liao, Hiltrud Muhle, Elena Parrini, Stephanie L. Leech, Jill R. Murrell, Algirdas Utkus, Francesca Ragona, Charles R. Newton, Alica M. Goldman, Terence John O'Brien, Benjamin M. Neale, Susanne Knake, Francesco Fortunato, Christopher M. McGraw, Grazia Annesi, George A. Tanteles, Susanne Schubert‐Bast, Lara E. Jehi, Biruté Tumiene, Sylvain Rheims, Annapurna Poduri, Elisabetta Amadori, Samuel Wiebe, Reetta Kälviäinen, Thomas N. Ferraro, Randi von Wrede, Erin L. Heinzen, Caitlin A. Bennett, Toshimitsu Suzuki, Henrike Heyne, Laura Canafoglia, Holger Lerche, Heinz Krestel, Ioanna Kousiappa, William Owen Pickrell, Dennis Dlugos, Jacqueline A. French, Danielle Molinari Andrade, Russell J. Buono, Felix Zahnert, Gábor Zsurka, Ingrid Eileen Scheffer, Ulrich Stephani, Gianpiero L. Cavalleri, Viola Doccini, Daniel H. Lowenstein, Karen Müller‐Schlüter, Robyn M. Busch, Tiziana Granata, Ilaria Sammarra, Gaëtan Lesca, Bernd A. Neubauer, Costin Leu, Alison Anderson, I‐Jun Chou, Antonella Riva, Barbara Castellotti, Chantal Depondt, Meng‐Han Tsai, Samuel F. Berkovic, Stefania Magri, Annika Faucon, Francesca Madia, Federico Zara, Johannes R. Lemke, Davide Mei, Beth R. Shiedley, Patrick Cossette, Larry Baum, Andreas Koupparis, Simona Balestrini, Mark I. Rees, Patrick May, Stefan Wolking, Mariagrazia Talarico, Michael E. Talkowski, Roland Krause, Luciana Midori Inuzuka, Raffaella Minardi, Elena Freri, Adam Strzelczyk, Luc Valton, Annalisa Vetro, Gerhard Kluger, Quratulain Zulfiqar Ali, Martha Feucht, Paolo Tinuper, Monica Gagliardi, L.G. Austin, Çiğdem Özkara, Ryan G. Wagner, Martin Krenn, Sanjay M. Sisodiya, Mark P. Fitzgerald, Andrew J. Cole, Leon G. Epstein, Carmen Barba, Angelo Labate, Lisa Ferguson, Symon M. Kariuki, Charlotte Lawthom, Yvonne Weber, Andreas van Baalen, Rainer Surges, Andreas Schulze‐Bonhage, Ahmad Beydoun, Laura Licchetta, Pınar Topaloğlu, Betül Baykan, Tobias Baumgartner, Kevin Haas, Zühal Yapıcı, Christian M. Boßelmann, Dalila Pinto, Marian Todaro, Siwei Chen, Chris Cotsapas, David B. Goldstein, David Lewis‐Smith, Ingo Helbig, Olivia Hoeper, Colin A. Ellis, Francesca Bisulli, Kathryn R. Sparks, Felicitas Becker, Gerhard Kurlemann, Jean Khoury, Ingo Borggräfe, Dilşad Türkdoğan, Meghan Evans, Anna J. Prentice, Maryam Erfanian Omidvar

October 25, 2025article en

1 citations

Abstract

No abstract available for this paper.

BrainVol. 149(2)

Children's Hospital of Philadelphia (US), University of Luxembourg (LU), Christian-Albrechts-Universität zu Kiel (DE), Hertie Institute for Clinical Brain Research (DE), University of Pennsylvania (US), University of Tübingen (DE)

Openalex Percentile: Top 22%

Ubiquitin and proteasome pathways

0.81

DOI Source OpenAlex

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