Rat Bone Marrow Mesenchymal Stem Cells‐Derived Exosomes Promote the Proliferation, Invasion, and Metastasis and Inhibit Apoptosis of Colorectal Cancer Stem Cells
Exosomes derived from rat BM-MSCs enhance the malignant phenotype and suppress apoptosis in human CRC-CSCs through the activation of the EMT pathway. These findings underscore the potential role of BM-MSC-derived exosomes in tumor microenvironment (TME) regulation and highlight their relevance as a potential therapeutic target.
Authors
- Haolong Qi
- Junbin Wang (ORCID: https://orcid.org/0009-0007-0590-6257)
- Weiyan Zou
- Shuai-Xia Yu (ORCID: https://orcid.org/0009-0004-8319-2665)
- Nan Yang
- Xingyu Chen
- S. H. Wei
- Tianxin Yu (ORCID: https://orcid.org/0009-0002-8959-1478)
- Jing Yu (ORCID: https://orcid.org/0009-0003-2656-9625)
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Stem Cells International
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/sci/7889271
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Anhui Province