A clinical control study of modified electroconvulsive therapy and sodium valproate as enhancement strategies for ultra-treatment-resistant schizophrenia
In this cohort of inpatients with UTRS, 8 weeks of MECT augmentation appeared to be more effective than sodium valproate in reducing overall psychotic symptoms. These findings should be considered preliminary, and neither intervention demonstrated short-term benefits for cognitive function. Future studies with longer follow-up periods are warranted to assess the durability of response and should include a clozapine-only control arm to confirm the true value of these augmentation strategies.
Authors
- Qinyu Lv (ORCID: https://orcid.org/0000-0002-2536-5749)
- J Shi
- Qi Yan (ORCID: https://orcid.org/0000-0002-0533-227X)
- Xiangdong Du (ORCID: https://orcid.org/0000-0002-9263-0178)
- Jenny I. Shen (ORCID: https://orcid.org/0000-0002-2993-403X)
- Peijuan Wang (ORCID: https://orcid.org/0000-0003-3648-1355)
- Chao Liu (ORCID: https://orcid.org/0000-0001-6637-1689)
- Xueyan Zhu
Institutions
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- Shanghai Mental Health Center (CN)
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
- Second People's Hospital of NanTong (CN)
Publication Details
- Journal
- Schizophrenia Research Cognition
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.scog.2025.100396
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00