Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study
Our findings, on the basis of nine-year follow-up, demonstrated that the decreases in fucosylation and galactosylation of IgG are significantly associated with the development of IS, potentially mediated by upregulation of chronic inflammatory processes. IgG N-glycosylation fingerprint might serve as a potential biomarker for predicting long-term risk of IS.
Authors
- Hualei Dong
- Liyong Zhang (ORCID: https://orcid.org/0000-0002-6952-7463)
- Shaocan Tang
- Shuyu Sun (ORCID: https://orcid.org/0000-0002-3078-864X)
- Mingzhu Zhang (ORCID: https://orcid.org/0000-0002-6975-4965)
- Haifeng Hou (ORCID: https://orcid.org/0000-0002-1131-1619)
- Siqi Ge (ORCID: https://orcid.org/0000-0003-1030-6890)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-5122-0869)
- Hongzhi Liu (ORCID: https://orcid.org/0000-0002-9811-2830)
- Yinghao Wang (ORCID: https://orcid.org/0000-0002-1928-0538)
- Jie Wang (ORCID: https://orcid.org/0009-0005-9100-4449)
- Jiheng Hao
- Qihua Guan
- C. F. Yu
- Xu Zan
Institutions
- Zaozhuang Municipal Hospital (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Beijing Institute of Neurosurgery (CN)
- Shandong Provincial Hospital (CN)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s12967-025-07236-1
- Citations
- 1
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shandong Province
- Shandong First Medical University