Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection

We show that host response in the nasopharynx can distinguish viral versus bacterial LRTI. These findings need to be replicated in larger cohorts with diverse LRTI etiologies.

Authors

Institutions

Publication Details

Journal
Journal of Clinical and Translational Science
Published
2025-01-01
DOI
https://doi.org/10.1017/cts.2025.10191
Primary Topic
Respiratory viral infections research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection

Micah T. McClain, Maria D. Iglesias-Ussel, Champica K. Bodinayake, Madureka Premamali et al.
Journal of Clinical and Translational Science
Respiratory viral infections research
article

Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection

Micah T. McClain, Maria D. Iglesias-Ussel, Champica K. Bodinayake, Madureka Premamali, Ephraim L. Tsalik, Sureni Weerasinghe, Rachel A. Myers, Jack Anderson, Thomas W. Burke, Robert Rolfe, L. Gayani Tillekeratne, Gaya B. Wijayaratne, Emily Ko, Nicholas O’Grady, Edwin Wilbur Woodhouse, Bradly P. Nicholson, Himali S. Jayasinghearachchi, Ruvini Kurukulasooriya, Christopher W. Woods, Christina Nix, Armstrong Obale, Jayani Gamage, Ajith Nagahawatte, Alana N. Brown, U.H.B.Y. Dilshan
article en

Abstract

We show that host response in the nasopharynx can distinguish viral versus bacterial LRTI. These findings need to be replicated in larger cohorts with diverse LRTI etiologies.

Journal of Clinical and Translational ScienceVol. 9(1)
University of Ruhuna (LK), Duke University (US), General Sir John Kotelawala Defence University (LK), Danaher (United States) (US), Durham VA Medical Center (US)
University of Cambridge, Duke Global Health Institute, Duke University, National Institute of Allergy and Infectious Diseases
Openalex Percentile: Top 58%
Respiratory viral infections research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.