Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection
We show that host response in the nasopharynx can distinguish viral versus bacterial LRTI. These findings need to be replicated in larger cohorts with diverse LRTI etiologies.
Authors
- Micah T. McClain (ORCID: https://orcid.org/0000-0001-8034-1136)
- Maria D. Iglesias-Ussel (ORCID: https://orcid.org/0000-0002-3679-9681)
- Champica K. Bodinayake (ORCID: https://orcid.org/0000-0003-1339-1883)
- Madureka Premamali (ORCID: https://orcid.org/0000-0001-5488-8293)
- Ephraim L. Tsalik (ORCID: https://orcid.org/0000-0002-6417-2042)
- Sureni Weerasinghe (ORCID: https://orcid.org/0000-0001-7337-8408)
- Rachel A. Myers (ORCID: https://orcid.org/0000-0003-0086-8339)
- Jack Anderson
- Thomas W. Burke (ORCID: https://orcid.org/0000-0003-0592-5822)
- Robert Rolfe (ORCID: https://orcid.org/0000-0001-9181-4023)
- L. Gayani Tillekeratne (ORCID: https://orcid.org/0000-0001-6012-7271)
- Gaya B. Wijayaratne (ORCID: https://orcid.org/0000-0002-8330-3597)
- Emily Ko (ORCID: https://orcid.org/0000-0002-9438-1566)
- Nicholas O’Grady (ORCID: https://orcid.org/0000-0001-8711-7508)
- Edwin Wilbur Woodhouse (ORCID: https://orcid.org/0000-0001-8285-3485)
- Bradly P. Nicholson (ORCID: https://orcid.org/0000-0001-9517-3876)
- Himali S. Jayasinghearachchi (ORCID: https://orcid.org/0000-0002-9188-1557)
- Ruvini Kurukulasooriya (ORCID: https://orcid.org/0000-0002-9783-4313)
- Christopher W. Woods (ORCID: https://orcid.org/0000-0001-9841-6183)
- Christina Nix
- Armstrong Obale (ORCID: https://orcid.org/0009-0006-5804-5377)
- Jayani Gamage
- Ajith Nagahawatte (ORCID: https://orcid.org/0000-0001-6481-0203)
- Alana N. Brown
- U.H.B.Y. Dilshan
Institutions
- University of Ruhuna (LK)
- Duke University (US)
- General Sir John Kotelawala Defence University (LK)
- Danaher (United States) (US)
- Durham VA Medical Center (US)
Publication Details
- Journal
- Journal of Clinical and Translational Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/cts.2025.10191
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cambridge
- Duke Global Health Institute, Duke University
- National Institute of Allergy and Infectious Diseases