Impact of adverse childhood experiences, post-traumatic stress disorder, dissociative disorders, and depression on dementia risk: a prospective analysis of associations and mediation in the UK Biobank cohort
Individuals with ACEs, PTSD, dissociative disorders, or depression appear to be at increased risk of dementia, potentially through both shared and unique associations. However, these findings should be interpreted with caution due to potential limitations in statistical power.
Authors
- Vasiliki Orgeta (ORCID: https://orcid.org/0000-0001-8643-5061)
- Thomas Ehring (ORCID: https://orcid.org/0000-0001-9502-6868)
- Mia Maria Günak (ORCID: https://orcid.org/0000-0001-5749-234X)
- Frederick K. Ho (ORCID: https://orcid.org/0000-0001-7190-9025)
Institutions
- University College Lahore (PK)
- LMU Klinikum (DE)
- Faculty (United Kingdom) (GB)
- University College London (GB)
- University of Glasgow (GB)
- Ludwig-Maximilians-Universität München (DE)
- Hologic (Germany) (DE)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10128
- Primary Topic
- Psychosomatic Disorders and Their Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Bundesministerium für Bildung und Forschung
- University College London Hospitals NHS Foundation Trust