Adipocyte‐specific deletion of the mineralocorticoid receptor improves glucose homeostasis and associates with <scp>FGF21</scp> ‐adiponectin signalling in obese male mice
Deletion of the adipocyte MR activates the FGF-21/β-klotho/adiponectin axis in obese male mice only. Thus, these data indicate that the dysfunctional FGF-21/β-klotho/adiponectin axis is associated with impaired glucose handling in a sex-specific manner.
Authors
- Sehyung Park
- Analia S. Loria (ORCID: https://orcid.org/0000-0002-9284-2146)
- Robert N. Helsley
- Meghan Turner (ORCID: https://orcid.org/0000-0001-8621-6168)
- Helen‐Rose Pangilinan
- Botshelo Angoma
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1111/dom.70230
- Citations
- 1
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81